Malaria remains one of the world's leading killer diseases with most of these deaths being in Africa. New tools, technologies and strategies are accelerating progress in even the most challenging environments by lowering costs, increasing efficiency and addressing risks like emerging drug and insecticide resistance. Innovative advances in fighting malaria are also helping to improve the way health systems fight other diseases. Various public-private research partnerships are currently developing efficient, effective innovative tools including malaria vaccines, more sensitive diagnostic tests and new drugs. This database showcases such innovations that have a difference towards malaria eradication globally for adaptation and scalling in the African region.